Tranexamic acid melasma
Tranexamic acid is a protease inhibitor that inhibits the catalysis of proteases on peptide bond hydrolysis, thereby preventing the activity of enzymes such as hairy proteases, thereby inhibiting the disorder of epidermal cell function in the dark spot and inhibiting melanin enhancement. Factor group, and completely cut off the pathway of melanin formation due to ultraviolet radiation. That is, the black spots are no longer thickened, enlarged, and increased, so that the pigmentation of the skin can be effectively prevented and improved.
What is Tranexamic acid?
It is a synthetic amino acid. Other names include hemolytic inflammation, hemostatic acid, tranexamic acid, etc. It has the pharmacological effect of stopping bleeding and anti-inflammation. It is used as a blood coagulation agent, and it has two kinds of injections and oral administration.
A class of fibrinolytic inhibitors that reversibly blocks the lysine binding site on the plasminogen molecule, resulting in the inability of plasminogen to be converted to plasmin, thereby effectively inhibiting fibrinolysis and production. Hemostasis. It is widely used in the fields of surgery, internal medicine, urology and obstetrics and gynecology to treat various hemorrhagic diseases and abnormal bleeding during surgery. It can directly block the activation of melanocytes, improve the active state of the dark spot activation factor group, prevent and improve the pigmentation of the skin, and thus has a certain cosmetic effect, and is the latest whitening ingredient.
Tranexamic acid in cosmetics
It is used in medicine for the diagnosis and treatment of aortic aneurysmal subarachnoid hemorrhage. It is called as a blood coagulation agent in the academic circle. It is found to have side effects of whitening the skin during the diagnosis and treatment process. Therefore, it is used in the treatment of liver spot and melanin precipitation. Use a prescription. The whitening mechanism of tranexamic acid is to simultaneously and rapidly inhibit the activity of tyrosine chymase and melanocytes, and to prevent melanin aggregation, and to block the path of progression of melanin deterioration due to ultraviolet irradiation. In the rapid whitening treatment, the tranexamic acid component is mainly combined with the vitamin C phosphate magnesium salt APMg, and Shiseido uses the transdermal absorption method to apply the leuco acid to the whitening component of the faded spot.
In recent years, tranexamic acid has been a patented whitening ingredient in skin care products. Years of clinical research have confirmed that tranexamic acid can quickly whiten and dilute spots, leaving skin with a white, soft, bright and crystal clear skin.
It is widely used in alum gel, keratin, firming, moisturizing lotion, whitening lotion, whitening essence, a series of whitening products that prevent melanin formation.
Compared with traditional whitening ingredients, tranexamic acid can express stable effects and is limited by the high temperature production environment. It does not require the protective transmission effect of various carriers, and can still achieve whitening effect without irritating effect. The maximum concentration of the announced use is 3%, and the amount of cosmetics used is about 0.5%.
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