D-ribose is an important component of ribonucleic acid (RNA), a genetic material in the body. It is a pivotal position in nucleosides, proteins, and fat metabolism, and has important physiological functions and broad application prospects. As a natural component present in all cells in vivo, D-ribose is closely related to the formation of adenosine and the regeneration of adenosine triphosphate (ATP), and is one of the most basic energy sources of life metabolism. It plays a key role in the metabolism of the heart and skeletal muscle, and can promote the recovery of ischemic tissue and local hypoxic tissue.
Nucleic acid drugs are an important means for humans to treat viruses, tumors and AIDS. D-ribose is an important intermediate for many nucleic acid drugs, and can be used for ribavirin, adenosine, thymidine, cytidine, fluoroadenosine nucleus. The production of many drugs such as glycosides, 2-methyladenosine, vitatoxin, pyrazole toxin, and adenosine.
The heart and skeletal muscles of the human body synthesize ATP slowly, while D-ribose accelerates the synthesis of ATP in the heart and skeletal muscle. Therefore, the heart and skeletal muscle are the organs and tissues most in need of D-ribose.
One of the magic of D-ribose: improve heart ischemia and improve heart function
Cardiac ischemia can reduce heart function and arrhythmia. Studies have confirmed that oral D-ribose can promote the production of ATP in cardiomyocytes, normalize the function of cardiomyocytes, thereby significantly improving cardiac function, protecting the heart during ischemia, and also protecting the arrhythmia induced by cardiac ischemia. The symptoms of panting, frequent flustering, chest tightness, and qi deficiency are significantly improved, and the quality of life is greatly improved.
D-Ribose Magic 2: Enhance body energy and relieve muscle soreness
The direct cause of fatigue is that the ATP production of muscle cells is insufficient, so that the energy of muscle activity is insufficient, and people have fatigue. D-ribose is the starting molecule for the synthesis of ATP, which is an important raw material for muscle synthesis of energy-derived ATP. Studies have confirmed that supplementation with D-ribose can improve the body’s ability to exercise, effectively resist fatigue and relieve muscle soreness.
The body’s three major nutrients, sugar, fat, and protein, can synthesize ATP in cells, but in general, sugar is the main raw material for the synthesis of ATP. There is a way for sugar to synthesize ATP. After a series of chemical reactions, glucose first produces 5-phosphate ribose, then generates purine nucleotides, and finally generates ATP to provide energy to the cells. This process is complicated and the response is slow.
The rate at which glucose produces adenine nucleotides and ATP is different in each organ. The study found that the highest rate was the kidney, followed by the liver, with the lowest rate of heart and skeletal muscle. This suggests that the ability of the heart and skeletal muscle to synthesize ATP is lower than that of the kidney and liver, that is, the tissue or organ most susceptible to damage to ATP synthesis is the heart and skeletal muscle.
D-ribose is absorbed by the intestine and is taken up by cardiomyocytes and skeletal muscle cells. Under the action of ribokinase, the phosphate group produced by ATP decomposition directly produces 5-phosphate ribose, which then rapidly generates ATP. Oral D-ribose can rapidly synthesize 5-phosphate ribose in myocardial and skeletal muscle cells through this reaction pathway, which in turn promotes the repair of adenine nucleotides and rapidly generates ATP. Glucose-forming 5-phosphate ribose process is complex and slow, and D-ribose formation of 5-phosphate ribose is simple and rapid. D-ribose formation of 5-phosphate ribose pathway compensates for the slow ATP supplementation of cardiomyocytes and skeletal muscle cells, and its role is more prominent when the body undergoes hypoxia, ischemia or high-intensity exercise. Studies have shown that in some muscle fibers, complete ATP regeneration takes 24 to 96 hours (1 to 4 days), allowing the body to fully recover from excessive exercise. After supplementing D-ribose, the rate of ATP production can be about 3 to 4 times faster, that is, the recovery of ATP storage can be reduced from 1 to 4 days to 6 to 24 hours.