Breif introduction of Proline

Proline, easy to deliquesce is not easy to crystallize, has a sweet taste. It is co-heated with the ninhydrin solution to form a yellow compound. Once in the peptide chain, hydroxylation can occur to form 4-hydroxyproline, which is an important component of animal collagen. Hydroxyproline is also present in a variety of plant proteins, particularly in relation to the formation of cell walls. Plants often have a significant accumulation of proline under drought, high temperature, low temperature, salt and other adverse conditions. It is widely used in clinical, biological materials, industrial and other fields.

Proline applications

1. Application in the pharmaceutical industry

Amino acid drugs. One of the raw materials for compound amino acid infusion. Used for malnutrition, protein deficiency, severe gastrointestinal disease, scald and protein supplementation after surgery. No obvious side effects.

2. Improve the cold resistance of plants

It is one of the components of plant proteins and can be found in a wide range of free states in plants.It is accumulated in many plants under drought and salt stress.In addition to being a plant cytoplasmic osmotic regulator, the accumulated proline plays an important role in stabilizing biological macromolecular structure, reducing cell acidity, relieving ammonia toxicity and regulating cell REDOX as an energy bank.

3. Internal action of organisms

In the organism, It is not just an ideal osmotic regulation substances, but also can be used as protection of material of membrane and enzymes and free radical scavenger, to protect the growth of plants under osmotic stress, with potassium ion of another important osmotic regulation substances and accumulate in the vacuoles, It can play a role in regulating the cytoplasm osmotic balance again

4. Industrial application

In the synthetic industry, It can participate in the induction of asymmetric reactions, and can be used as a catalyst for hydrogenation, polymerization, water medium and other reactions. As a catalyst for such reactions, proline has the characteristics of strong activity and good stereospecificity.

5. Other fields of application

  • It and its derivatives are usually used as symmetric catalysts in organic reactions. The reduction of CBS and the catalytic aldol condensation of it are prominent examples.
  • At the time of brewing, the protein is rich in proline-bound proline, which produces haze (turbidity).
  • Synthetic raw materials for cholesteryl ester inhibitors. 
  • Flavoring agent, which reacts with sugar to react with amino-hydrogen group to form a substance with special aroma.

6. Experimental application
It is in its natural form, one of the main components of collagen. The DL-type is prepared by using gelatin as a raw material, and hydrolyzing by hydrochloric acid and the like to obtain the hydrochloride salt. It is a biochemical reagent for biochemical and nutritional research, microbial testing, and preparation of a medium. L-form is obtained by esterification and reduction of L-glutamic acid and absolute ethanol.

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